Product Spotlight

What is Clomiphene?

First developed in the late 1950’s and early 1960’s, Clomiphene is a substance that is regularly used in medications prescribed to women that struggle to produce eggs but want to bare a child.  Most frequently marketed under the name brand Serophene, Clomiphene has been regularly treating infertility in women for the better part of four decades now.

Clomiphene, sometimes written as Clomifene, was approved for medical use in the United States, back in 1967.  Attractive because it is a synthetic selective estrogen receptor modulator, or SERM, that doesn’t cost much to manufacture.  This keeps the sale and resale price reasonably low. On, we offer pure, USA developed Clomiphene for research uses at a modest price of $27.99 for 30ml.

Assisted Reproductive Technology

Clomiphene’s discovery and efficacy ushered in a new era for fertility treatment.  A whole new arm of medicine was created as a result of the acceptance of a safe female fertility product.  Medications to increase sperm count as well as other substances that improve egg or sperm health have been researched, developed, and approved because of the success of Clomiphene.  

In the most recent phases of assisted reproductive technology, sexual intercourse is bypassed completely.  In vitro fertilization has allowed people that couldn’t find a partner or weren’t able to have intercourse for medical reasons to bare their own children.  As time marches on assisted reproductive technology methods continue to flourish as modern technology gets better.

Clomiphene Adverse Effects

Any time you’re altering natural estrogen levels or naturally occurring processes that rely on estrogen, you’re going to be opening the door to uncomfortable side effects.  Being one of the most key hormones in humans, this comes as no surprise. Here are a list of the most common side effects that women supplementing with clomiphene have to prepare for:

  • Uterine bleeding alterations – Menstruation cycles are most frequently affected when estrogen levels are altered in women.  Some may bleed more profusely or more frequently. Some women may go completely unaffected while still others spot periodically nearly daily.
  • Cysts and Ovarian Enlargement – Unfortunately, a little over a third of the women who use clomiphene are going to develop ovarian cysts.  Most women view it as a small price to pay. Cysts are relatively harmless but uncomfortable so long as they’re monitored.
  • Headache/Nausea/Stomach Pain – To be expected.  Found with almost every SERM or SARM.

Individuals who are particularly sensitive to the medication may experience visual disturbances or hallucinations.  These seem extremely infrequent and are rarely a concern of physicians.

Undeniably Effective

There are any number of studies available to the public that support clomiphene and the fast and favorable results it relentlessly brings to the table.  In fact, in recent years, some of the most learned people in the medical community have been comparing clomiphene to other alternatives and have found that clomiphene is “still the first-line therapy for ovulation induction.”  The only alarming point worth mentioning is that while Clomiphene yields significantly better pregnancy results, the alternatives may have lower miscarriage rates than Clomiphene.

1 Rodin, D A, et al. “Cycle Abnormalities in Infertile Women with Regular Menstrual Cycles: Effects of Clomiphene Citrate Treatment.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, July 1994,

2 Csokmay, J M, and J L Frattarelli. “Basal Ovarian Cysts and Clomiphene Citrate Ovulation Induction Cycles.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, June 2006,

3 Sovino, H, et al. “Clomiphene Citrate and Ovulation Induction.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine,

4 Fariba Seyedoshohadaei, M.D., Farnaz Zandvakily, M.D., and Shole Shahgeibi, M.D. “Comparison of the effectiveness of clomiphene citrate, tamoxifen and letrozole in ovulation induction in infertility due to isolated unovulation.” Iran Journal of Reproductive Medicine., U.S. National Library of Medicine, Nov. 2012,

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