What is Melanotan?
Melanotan, sometimes referred to as Melanotan-II, or Melanotan 2, is a synthetic (lab-made) version of alpha-melanocyte stimulating hormone (a-MSH) a naturally occurring hormone found in humans.
Originally developed at the University of Arizona, Melanotan-2 was the brainchild of researchers who claimed that when administered into the human body, this synthetic peptide would act as a sunless tanner, as it would allow the skin to tan from the inside. Researchers further backed up their claims for the benefits of this peptide by advertising that it would enable people to achieve the tanned skin they desired without exposing themselves to the damaging effects of the sun’s UV rays.
After in-depth research, the Italian Medicines Agency was the first governmental health organization to authorize the use of Melanotan-2 for medicinal purposes, stating that it proved to be therapeutic in reducing pain due to photosensitivity.
Various Studies On Melanotan
Numerous studies have been conducted to determine the effectiveness of Melanotan II in a variety of applications.
In a study conducted by Dorr, et al, it was found that human subjects who were administered Melanotan experienced a dramatic change in the pigmentation, or the darkening, of their skin. This skin darkening was noticeably visible after just five applications of the peptide, which was applied via subcutaneous injections every day. In this same study, it was also noted that the peptide had a positive impact on penile erection in male subjects.
In another study that was conducted by Wessells, et al, it was determined that Melanotan-II is an effective treatment for erectile dysfunction in men. In this study, 8 out of 10 men who were treated with the medication we able to experience erections. Decreased hunger was also a side effect noted in the subjects, which lead to additional studies for the possible use of melanotan for the treatment of obesity.
A study conducted by Banno, in which rats were the subject of the intake of Melanotan II, it was found that this peptide had a significant effect on satiety. In this study, the rats food intake decreased, which lead to the decrease in their body weight. It was also found that their sensitivity to insulin and their tolerance to glucose were improved.
Implications of Melanotan
The initial research findings have suggested that Melanotan may be used in a number of applications, including:
- Sunless tanning, as it enhances the pigmentation of the skin, making it darker without exposure to damaging UV rays.
- Treatment for erectile dysfunction, as it was found that the majority of male subjects experienced pineal erection after Melanotan II was injected.
- A treatment for obesity, as studies on humans, as well as lab rats, have shown that hunger levels decreased when Melanotan II was administered.
This unique research peptide has the potential to provide three desired results: sunless tanning, erectile dysfunction treatment, and as a possible treatment for obesity. Further studies and research on the peptide are in progress and we may one day soon find it prescribed by doctors for any of these purposes.